Serum S100A8 as an early diagnostic biomarker in patients with community-acquired pneumonia

Introduction Limited studies have suggested that calprotectin may take part in the pathophysiology of community-acquired pneumonia (CAP). Nevertheless, there is no clinical study analysing role S100A8 CAP patients. The objective this was to analyse association serum with severity and determine cut-off values for predictive power based on a cross-sectional study. Material methods A total 200 patients 100 normal subjects were recruited. Demographic data, information, collected admission. inflammatory cytokines detected using ELISA RT-PCR. All statistical analyses performed SPSS 19.0. Results Serum increased gradually parallel scores. positively correlated scores, blood routine parameters, cytokines. Furthermore, univariate multivariate logistical regression revealed positive associations between CRB-65, PSI, CURXO. Moreover, capacity determined by ROC curve analysis. area under curves 0.855 0.893, respectively. Mechanistic analysis found knockdown alleviated streptococcus pneumoniae-evoked A549 cells. Conclusions admission associated CAP. alleviates cells, indicating exert significant effect could be an early diagnostic biomarker